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      Identification of chemical constituents in SiWu decoction by UHPLC-DAD-TOF/MS

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          Summary

          An efficient and robust method for analyzing constituents of a well-known traditional Chinese medicine (TCM) formula SiWu decoction (SWD) contains Angelicae Sinensis Radix (ASR), Chuanxiong Rhizoma (CR), Paeoniae Radix Alba (PRA), and Rehmanniae Radix Praeparata (RRP) by ultra high-performance liquid chromatography (UHPLC)/time-of-flight mass spectrometry (TOF-MS) was established. The method efficiently applied to the separation of 75 compounds, including organic acids, phthalides, phenylpropanoid glycosides, iridoid glycosides, monoterpene glycosides, and galloyl glycosides in the complex prescription, 52 compounds in this study can be unambiguously identified or tentatively characterized. The separation was achieved within 20 min at the optimized chromatographic conditions. Our study provided a reliable and high-efficient method for the understanding of the chemical basis of SWD.

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          Author and article information

          Journal
          1326
          121093
          Acta Chromatographica
          A Sponsored Open Access Journal on Chromatography
          Acta Chromatographica
          Akadémiai Kiadó, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
          1233-2356
          2083-5736
          1 September 2014
          : 26
          : 3
          : 517-537
          Affiliations
          [ 1 ] The First Affiliated Hospital of Nanjing University of Chinese Medicine, West Phoenix Street, 150-1, 210036, Nanjing, China
          [ 2 ] Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Xianlin Road 138, 210023, Nanjing, China
          Author notes
          Article
          10
          10.1556/AChrom.26.2014.3.10
          4ea6550a-51fb-47de-9158-e41f4296cb43
          History
          Categories
          Original Research Papers

          Materials properties,Nanomaterials,Chemistry,Nanotechnology,Analytical chemistry,Thin films & surfaces
          Chuanxiong Rhizoma , Paeoniae Radix Alba ,SiWu decoction, Rehmanniae Radix Praeparata , Angelicae Sinensis Radix

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