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      Subcellular localization and membrane topology of 17β-hydroxysteroid dehydrogenases

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      Molecular and Cellular Endocrinology
      Elsevier BV

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          Abstract

          The 17β-hydroxysteroid dehydrogenases (17β-HSDs) comprise enzymes initially identified by their ability to interconvert active and inactive forms of sex steroids, a vital process for the tissue-specific control of estrogen and androgen balance. However, most 17β-HSDs have now been shown to accept substrates other than sex steroids, including bile acids, retinoids and fatty acids, thereby playing unanticipated roles in cell physiology. This functional divergence is often reflected by their different subcellular localization, with 17β-HSDs found in the cytosol, peroxisome, mitochondria, endoplasmic reticulum and in lipid droplets. Moreover, a subset of 17β-HSDs are integral membrane proteins, with their specific topology dictating the cellular compartment in which they exert their enzymatic activity. Here, we summarize the present knowledge on the subcellular localization and membrane topology of the 17β-HSD enzymes and discuss the correlation with their biological functions.

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          Author and article information

          Journal
          Molecular and Cellular Endocrinology
          Molecular and Cellular Endocrinology
          Elsevier BV
          03037207
          July 2018
          July 2018
          Article
          10.1016/j.mce.2018.07.003
          30864548
          4eacb4b2-2e7b-4622-8fc5-075bea43cadd
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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