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      Development of Negative Feedback Control of the Hypothalamo-Pituitary-Gonadal Axis in the Male Rat Fetus

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          Pregnant rats were passively immunized against testosterone by injections of rabbit antibodies against testosterone. Fetuses were studied daily starting at day 18 of gestation. Testosterone antibodies were detected in all fetal plasma samples. At day 18 of gestation testicular testosterone content – as an index of gonadotropin stimulation – was unchanged even though circulating free testosterone was reduced by antibody binding. However, at day 19 and all subsequent days of gestation testicular testosterone content was significantly higher in immunized fetuses compared to the controls. These results indicate that in the male rat the negative feedback between testes and the hypothalamopituitary system develops between days 18 and 19 of gestation.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 16
          : 3
          : 182-187
          Division of Pediatric Endocrinology, Children’s Hospital of the University of Munich, FRG
          179500 Horm Res 1982;16:182–187
          © 1982 S. Karger AG, Basel

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          Pages: 6


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