Investigation of ototoxicity of artesunate as add-on therapy in patients with metastatic or locally advanced breast cancer: new audiological results from a prospective, open, uncontrolled, monocentric phase I study.

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Abstract

Artesunate (ART) has been used for a long time in the treatment of Plasmodium falciparum malaria and has been considered safe. The present phase I study aimed to determine the daily dose of ART that is well tolerated as add-on therapy in patients with breast cancer for 4 weeks of therapy. Ototoxicity could be a potential safety concern in settings different from malaria. Therefore, comprehensive audiological assessment was essential.

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Journal

Journal ID (iso-abbrev): Cancer Chemother. Pharmacol.

Title: Cancer chemotherapy and pharmacology

ISSN (Electronic): 1432-0843

ISSN (Print): 0344-5704

Publication date (Electronic): Feb 2016

Volume: 77

Issue: 2

Affiliations

[1 ] Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

[2 ] Naturopathy and Integrative Medicine, Department of Gynecological Endocrinology and Reproductive Medicine, University Women's Hospital, Heidelberg, Germany.

[3 ] Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital, Heidelberg, Germany.

[4 ] Department of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

[5 ] Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. serkan.sertel@med.uni-heidelberg.de.

Article

Publisher Item ID: 10.1007/s00280-016-2960-7

DOI: 10.1007/s00280-016-2960-7

PubMed ID: 26793976

SO-VID: 4ed3fe54-6dfb-463b-bc4e-c1aeab759afa

History

Keywords: Artesunate,Breast cancer,Metastasis,Ototoxicity

Data availability:

Keywords: Artesunate, Breast cancer, Metastasis, Ototoxicity

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