Safety and Efficacy of Botulinum Toxin A in Children Undergoing Lower Limb Lengthening and Deformity Correction: Results of a Double-blind, Multicenter, Randomized Controlled Trial.

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Abstract

Lengthening of the lower limb is a complex procedure in which pain management and complications such as pin-site infections and muscle contractures impact the family and affect the child's quality of life. As a result, the paralytic and antinociceptive actions of neurotoxins may be indicated in managing these complications; however, few studies have explored ways to improve outcomes after lengthenings. The objective of this study was to evaluate the safety and efficacy of botulinum toxin A (BTX-A) in children undergoing lower limb lengthenings and deformity correction.

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Journal

Journal ID (iso-abbrev): J Pediatr Orthop

Title: Journal of pediatric orthopedics

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1539-2570

ISSN (Print): 0271-6798

Publication date (Electronic): Jan 2016

Volume: 36

Issue: 1

Affiliations

[1 ] *Shriners Hospital for Children, Montreal Children's Hospital and Division of Orthopedics, McGill University †Shriners Hospital for Children, Montreal, Canada **Research Institute-McGill University Health Center ††Shriners Hospital for Children, McGill University, Montreal, Canada ¶Hospital for Sick Children, Toronto, Canada ‡Shriners Hospital for Children, Portland, OR §Alfred I duPont Hospital for Children, Wilmington, DE ∥Shriners Hospital for Children, Philadelphia, PA #Shriners Hospital for Children, Honolulu, HI.

Article

DOI: 10.1097/BPO.0000000000000398

PubMed ID: 25730290

SO-VID: 4eea7f0b-21ed-4c04-9ca7-d29b55dfc0c5

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