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Pro-opiocortin fragments in human and rat brain: β-endorphin and α-MSH are the predominant peptides
June 1980
June 1980
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Abstract
The 'pro-opiocortin' fragments, beta-lipotropin, beta-endorphin, ACTH and alpha-MSH,
were estimated in discrete areas of rat and human brain and pituitaries by means of
radioimmunoassay in combination with gelfiltration. These peptides exhibited parallel
patterns of distribution, but with beta-endorphin and alpha-MSH predominant in the
brain of rat and man, and, in contrast, their respective precursors. beta-LPH and
ACTH predominant in the adenohypophysis of rat and man. These data may be indicative
of important differences in post-translational processing of 'pro-opiocortin' between
these contrasting tissues.