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      The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature.

      Medicine

      therapeutic use, Adolescent, Adult, Age Factors, Aged, Cardiovascular Diseases, complications, Child, Child, Preschool, Eosinophilia, diagnosis, drug therapy, Eosinophils, Female, Hematopoietic System, Humans, Kidney Diseases, Leukemia, Liver Diseases, Lung Diseases, Male, Middle Aged, Neurologic Manifestations, Prognosis, Pulmonary Eosinophilia, Sex Factors, Skin Manifestations, Steroids

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          Abstract

          Several closely related disease entities make up the idiopathic hypereosinophilic syndrome (HES). The syndrome is manifest by persistent and prolonged eosinophilia with organ damage. A group of 14 patients had hematologic, cardiac, and neurologic abnormalities attributable to this disease. Patient survival and response to chemotherapy was significantly better in this group than in previously reported patients. The etiology of HES remains unknown, as does the mechanism of tissue damage.

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          1090795

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