5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Targeted drug delivery to the brain using magnetic nanoparticles.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Brain capillary endothelial cells denote the blood-brain barrier (BBB), and conjugation of nanoparticles with antibodies that target molecules expressed by these endothelial cells may facilitate their uptake and transport into the brain. Magnetic nanoparticles can be encapsulated in liposomes and carry large molecules with therapeutic potential, for example, siRNA, cDNA and polypeptides. An additional approach to enhance the transport of magnetic nanoparticles across the BBB is the application of extracranially applied magnetic force. Stepwise targeting of magnetic nanoparticles to brain capillary endothelial cells followed by transport through the BBB using magnetic force may prove a novel mechanism for targeted therapy of macromolecules to the brain.

          Related collections

          Author and article information

          Journal
          Ther Deliv
          Therapeutic delivery
          Future Science, LTD
          2041-6008
          2041-5990
          2015
          : 6
          : 10
          Affiliations
          [1 ] Laboratory of Neurobiology, Section of Biomedicine, Department of Health Science & Technology, Aalborg University, Fredrik Bajers Vej 3 B, 9220 Aalborg East, Denmark.
          Article
          10.4155/tde.15.56
          26446407

          Comments

          Comment on this article