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      An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota

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          Metabolic syndrome characterized by obesity, hyperglycemia and liver steatosis is becoming prevalent all over the world. Herein, a water insoluble polysaccharide (WIP) was isolated and identified from the sclerotium of Poria cocos, a widely used Traditional Chinese Medicine. WIP was confirmed to be a (1-3)- β-D-glucan with an average Mw of 4.486 x 10 6 Da by NMR and SEC-RI-MALLS analyses. Furthermore, oral treatment with WIP from P. cocos significantly improved glucose and lipid metabolism and alleviated hepatic steatosis in ob/ob mice. 16S DNA sequencing analysis of cecum content from WIP-treated mice indicated the increase of butyrate-producing bacteria Lachnospiracea, Clostridium. It was also observed that WIP treatment elevated the level of butyrate in gut, improved the gut mucosal integrity and activated the intestinal PPAR- γ pathway. Fecal transplantation experiments definitely confirmed the causative role of gut microbiota in mediating the benefits of WIP. It is the first report that the water insoluble polysaccharide from the sclerotium of P. cocos modulates gut microbiota to improve hyperglycemia and hyperlipidemia. Thereby, WIP from P. cocos, as a prebiotic, has the potential for the prevention or cure of metabolic diseases and may elucidate new mechanism for the efficacies of this traditional herbal medicine on the regulation of lipid and glucose metabolism.

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          Author and article information

          Chinese Journal of Natural Medicines
          20 January 2019
          : 17
          : 1
          : 3-14
          1 School of Life Sciences, University of Science and Technology of China, Hefei 230026, China
          2 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
          3 University of Chinese Academy of Sciences, Beijing, 100049, China
          Author notes
          *Corresponding author: LIU Hong-Wei, Tel: 86-10-64806074, E-mail: liuhw@ 123456im.ac.cn

          These authors have no conflict of interest to declare.

          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funded by: National Key R&D program of China
          Award ID: 2018YFD0400203
          Funded by: Key Research Program of the Chinese Academy of Sciences
          Award ID: KFZD-SW-219
          Funded by: Youth Innovation Promotion Association of CAS
          Award ID: 2014074
          This work was supported by the National Key R&D program of China (No. 2018YFD0400203), the Strategic Biological Resources Service Network programme of CAS and Key Research Program of the Chinese Academy of Sciences (No. KFZD-SW-219) and the Youth Innovation Promotion Association of CAS (No. 2014074).
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