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      Depression and anxiety symptoms in cardiac patients: a cross-sectional hospital-based study in a Palestinian population

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          Abstract

          Background

          Mental health problems have an adverse effect on the course of cardiac disease. The integration of their diagnosis and treatment into cardiology care is generally poor. It is particularly challenging in cultural environments where mental health problems are stigmatized. The objective of the current study was to investigate the proportion of cardiac patients with depression and anxiety as well as factors associated with the presence of these symptoms in a Palestinian population.

          Methods

          This cross-sectional hospital-based study was conducted on patients consecutively admitted with a new or existing cardiac diagnosis to one of the four main hospitals in Nablus, Palestine over an eight-month period. Data was obtained from hospital medical charts and an in-person interview, using a structured questionnaire with a sequence of validated instruments. All subjects were screened for depression and anxiety using the Cardiac Depression Scale (CDS) and the Depression Anxiety Stress Scale (DASS-42). Multivariate ordered logistic regression analyses were performed to identify factors among four categories (socio-demographic, clinical, psychosocial, lifestyle) independently associated with depression and anxiety.

          Results

          In total, 1053 patients with a confirmed cardiac diagnosis were included in the study with a participation rate of 96%. Based on the CDS and DASS-42, 54% met the criteria for severe depression (CDS > 100) and 19.2% for severe-to-very severe anxiety (DASS-anxiety > 15), respectively. Symptoms of depression and anxiety were more prevalent among females and less educated patients. Factors independently associated with both depressive and anxiety symptoms were post-traumatic stress disorder symptoms, low level of self-esteem, high somatic symptoms, low physical and mental health component scores, active smoking, physical inactivity, and longer disease duration. Patients with depressive and anxiety symptoms also reported poor social support and lower resilience.

          Conclusion

          There was a high level of depression and anxiety in this sample of cardiac patients. The results point to characteristics of patients in particular need for mental health screening and suggest possible targets for intervention such as strengthening of social support and of physical activity. The integration of mental health services into cardiac rehabilitation in Palestine and comparable cultural settings is warranted from the time of first diagnosis and onward.

          Electronic supplementary material

          The online version of this article (10.1186/s12889-019-6561-3) contains supplementary material, which is available to authorized users.

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          Most cited references49

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          Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies.

          With negative treatment trials, the role of depression as an aetiological or prognostic factor in coronary heart disease (CHD) remains controversial. We quantified the effect of depression on CHD, assessing the extent of confounding by coronary risk factors and disease severity. Meta-analysis of cohort studies measuring depression with follow-up for fatal CHD/incident myocardial infarction (aetiological) or all-cause mortality/fatal CHD (prognostic). We searched MEDLINE and Science Citation Index until December 2003. In 21 aetiological studies, the pooled relative risk of future CHD associated with depression was 1.81 (95% CI 1.53-2.15). Adjusted results were included for 11 studies, with adjustment reducing the crude effect marginally from 2.08 (1.69-2.55) to 1.90 (1.49-2.42). In 34 prognostic studies, the pooled relative risk was 1.80 (1.50-2.15). Results adjusted for left ventricular function result were available in only eight studies; and this attenuated the relative risk from 2.18 to 1.53 (1.11-2.10), a 48% reduction. Both aetiological and prognostic studies without adjusted results had lower unadjusted effect sizes than studies from which adjusted results were included (P<0.01). Depression has yet to be established as an independent risk factor for CHD because of incomplete and biased availability of adjustment for conventional risk factors and severity of coronary disease.
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            Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes.

            This article describes a meta-analysis of published associations between depression and heart failure (HF) in regard to 3 questions: 1) What is the prevalence of depression among patients with HF? 2) What is the magnitude of the relationship between depression and clinical outcomes in the HF population? 3) What is the evidence for treatment effectiveness in reducing depression in HF patients? Key word searches of the Medline and PsycInfo databases, as well as reference searches in published HF and depression articles, identified 36 publications meeting our criteria. Clinically significant depression was present in 21.5% of HF patients, and varied by the use of questionnaires versus diagnostic interview (33.6% and 19.3%, respectively) and New York Heart Association-defined HF severity (11% in class I vs. 42% in class IV), among other factors. Combined results suggested higher rates of death and secondary events (risk ratio = 2.1, 95% confidence interval 1.7 to 2.6), trends toward increased health care use, and higher rates of hospitalization and emergency room visits among depressed patients. Treatment studies generally relied on small samples, but also suggested depression symptom reductions from a variety of interventions. In sum, clinically significant depression is present in at least 1 in 5 patients with HF; however, depression rates can be much higher among patients screened with questionnaires or with more advanced HF. The relationship between depression and poorer HF outcomes is consistent and strong across multiple end points. These findings reinforce the importance of psychosocial research in HF populations and identify a number of areas for future study.
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              Depression and Coronary Heart Disease

              Circulation, 118(17), 1768-1775
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                Author and article information

                Contributors
                hala.allabadi@swisstph.ch
                abdulsalam.alkaiyat@swisstph.ch
                asjk1994@gmail.com
                ahmad_hammoudi@outlook.com
                hiba.od@hotmail.com
                jamilshtayeh@yahoo.com
                manaltaha20@gmail.com
                christian.schindler@swisstph.ch
                elisabeth.zemp@swisstph.ch
                hajsaleem@gmail.com
                nicole.probst@swisstph.ch
                Journal
                BMC Public Health
                BMC Public Health
                BMC Public Health
                BioMed Central (London )
                1471-2458
                26 February 2019
                26 February 2019
                2019
                : 19
                : 232
                Affiliations
                [1 ]ISNI 0000 0004 0587 0574, GRID grid.416786.a, Department of Epidemiology and Public Health, , Swiss Tropical and Public Health Institute, ; Socinstrasse 57, P.O. Box, 4002 Basel, Switzerland
                [2 ]ISNI 0000 0004 1937 0642, GRID grid.6612.3, University of Basel, ; Petersplatz 1, 4001 Basel, Switzerland
                [3 ]ISNI 0000 0004 0631 5695, GRID grid.11942.3f, Faculty of Medicine and Health Sciences, , An-Najah National University, ; Rafidia Street, P.O. Box 7, Nablus, Palestine
                [4 ]ISNI 0000 0004 0631 5695, GRID grid.11942.3f, An-Najah National University Hospital, ; Asira Street, Nablus, Palestine
                [5 ]ISNI 0000 0004 1936 7603, GRID grid.5337.2, School of Clinical Sciences, , University of Bristol, ; 69 St Michael’s Hill, Bristol, BS2 8DZ UK
                [6 ]ISNI 0000 0001 2193 314X, GRID grid.8756.c, Institute of Cardiovascular and Medical Sciences, Glasgow University, ; 126 University Place, Glasgow, G12 8TA UK
                Article
                6561
                10.1186/s12889-019-6561-3
                6390372
                30808333
                4f4181aa-992c-41d1-928f-84c33e2c46b4
                © The Author(s). 2019

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 28 October 2018
                : 18 February 2019
                Funding
                Funded by: SWISS GOVERNMENT EXCELLENCE SCHOLARSHIP
                Award ID: 2016.0951
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2019

                Public health
                depression,anxiety,cardiovascular diseases,predictors,prevalence,cardiac rehabilitation
                Public health
                depression, anxiety, cardiovascular diseases, predictors, prevalence, cardiac rehabilitation

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