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      Host phylogeny constrains cross-species emergence and establishment of rabies virus in bats.

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          Abstract

          For RNA viruses, rapid viral evolution and the biological similarity of closely related host species have been proposed as key determinants of the occurrence and long-term outcome of cross-species transmission. Using a data set of hundreds of rabies viruses sampled from 23 North American bat species, we present a general framework to quantify per capita rates of cross-species transmission and reconstruct historical patterns of viral establishment in new host species using molecular sequence data. These estimates demonstrate diminishing frequencies of both cross-species transmission and host shifts with increasing phylogenetic distance between bat species. Evolutionary constraints on viral host range indicate that host species barriers may trump the intrinsic mutability of RNA viruses in determining the fate of emerging host-virus interactions.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          Aug 06 2010
          : 329
          : 5992
          Affiliations
          [1 ] Rabies Team, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. dstrike@uga.edu
          Article
          329/5992/676
          10.1126/science.1188836
          20689015
          4f5a78ff-89d3-402c-8ee5-7ec09f6f4340
          History

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