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      MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles.

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          Abstract

          Rupture of vulnerable atherosclerotic plaque is the major pathological cause of luminal thrombosis in acute coronary syndromes. Since foamy macrophages have been identified as a prominent component in vulnerable atherosclerotic lesions and osteopontin (OPN) is reported to be highly expressed in foamy macrophages, OPN could be a potential target for vulnerable atherosclerotic plaque imaging. The current study designed an OPN-specific MRI/optical dual-modality probe to detect vulnerable plaques. Fluorescence imaging revealed that 24 h after injection of the Cy5.5-OPN-DMSA-MNPs (COD-MNPs), the atherosclerotic plaques in carotid artery exhibited significant higher signals in high fat diet (HFD) fed mice in comparison to the group injected with Cy5.5-IgG-DMSA-MNPs (CID-MNPs) or normal diet fed group injected with COD-MNPs (1.87 ± 0.19 × 1010 vs. 0.74 ± 0.04 × 1010, 0.73 ± 0.03 × 1010 p/sec/cm2/sr, P < 0.05). Meanwhile, MRI displayed stronger T2 contrast enhancement 24 h post-injection at the area of atherosclerotic plaques in the carotid of HFD fed group injected with COD-MNPs than group injected with CID-MNPs or normal diet fed group injected with COD-MNPs (post/pre signal ratio: 0.64 ± 0.04 vs. 0.95 ± 0.02, 0.98 ± 0.01, P < 0.05). As a dual-modality molecular probe, the resulting COD-MNPs conjugates exhibit promising potentials for noninvasive detection of vulnerable atherosclerotic plaque in vivo.

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          Author and article information

          Journal
          Biomaterials
          Biomaterials
          Elsevier BV
          1878-5905
          0142-9612
          January 2017
          : 112
          Affiliations
          [1 ] Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
          [2 ] Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
          [3 ] Department of Hepato-Biliary and Pancreto-Splenic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
          [4 ] Laboratory of the Animal Center, Academy of Military Medical Science, Beijing, 100850, China.
          [5 ] Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
          [6 ] Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
          [7 ] Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing, 100190, China.
          [8 ] Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing, 100190, China. Electronic address: gaomy@iccas.ac.cn.
          [9 ] Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: wind8828@gmail.com.
          Article
          S0142-9612(16)30553-1
          10.1016/j.biomaterials.2016.10.011
          27788352
          4f5b94df-2e4a-4bfa-8251-c7ac0a4a58af

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