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In vitro selection of RNA molecules that bind specific ligands.

Nature

metabolism, Triazines, Transcription, Genetic, Templates, Genetic, isolation & purification, biosynthesis, RNA, Polymerase Chain Reaction, Nucleic Acid Conformation, Molecular Structure, Molecular Sequence Data, Ligands, chemical synthesis, DNA, Coloring Agents, Cloning, Molecular, Chromatography, Affinity, Binding Sites, Base Sequence

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      Abstract

      Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 10(10) random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.

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      Journal
      10.1038/346818a0
      1697402

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