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      Meta-analysis of cyclooxygenase-2 (COX-2) 765G>C polymorphism and Alzheimer’s disease

      , , , ,
      Journal of Clinical Neuroscience
      Elsevier BV

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          Abstract

          The cyclooxygenase-2 (COX-2) 765G>C polymorphism has been extensively investigated for association with Alzheimer's disease (AD). However, results of different studies have been inconsistent. The aim of the present meta-analysis was to evaluate the association between the 765G>C polymorphism of the COX-2 gene and susceptibility to AD. We searched all related subjects in PubMed, Embase, SinoMed, and China Knowledge Resource Integrated Database and identified seven studies that reported a relationship between the COX-2 765G>C polymorphism and AD. A total of 1260 cases and 1112 controls were included in the seven studies. Our data suggest that the COX-2 765G>C polymorphism may decrease the risk of AD in five genetic models. As a result, this meta-analysis suggests the 765G>C polymorphism of the COX-2 gene may be a protective factor for AD. As our sample size was limited, large-scale, well-designed studies are necessary to validate the association between the COX-2 765G>C polymorphism and AD.

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          Author and article information

          Journal
          Journal of Clinical Neuroscience
          Journal of Clinical Neuroscience
          Elsevier BV
          09675868
          September 2016
          September 2016
          : 31
          : 4-9
          Article
          10.1016/j.jocn.2015.11.032
          27443496
          4f6da4c4-3358-4a5a-947b-b1bca17cc0fc
          © 2016

          https://www.elsevier.com/tdm/userlicense/1.0/

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