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Abstract
The cyclooxygenase-2 (COX-2) 765G>C polymorphism has been extensively investigated
for association with Alzheimer's disease (AD). However, results of different studies
have been inconsistent. The aim of the present meta-analysis was to evaluate the association
between the 765G>C polymorphism of the COX-2 gene and susceptibility to AD. We searched
all related subjects in PubMed, Embase, SinoMed, and China Knowledge Resource Integrated
Database and identified seven studies that reported a relationship between the COX-2
765G>C polymorphism and AD. A total of 1260 cases and 1112 controls were included
in the seven studies. Our data suggest that the COX-2 765G>C polymorphism may decrease
the risk of AD in five genetic models. As a result, this meta-analysis suggests the
765G>C polymorphism of the COX-2 gene may be a protective factor for AD. As our sample
size was limited, large-scale, well-designed studies are necessary to validate the
association between the COX-2 765G>C polymorphism and AD.