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Dynamic SPECT measurement of absolute myocardial blood flow in a porcine model.

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      Abstract

      Absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) provide incremental diagnostic and prognostic information over relative perfusion alone. Recent development of dedicated cardiac SPECT cameras with better sensitivity and temporal resolution make dynamic SPECT imaging more practical. In this study, we evaluate the measurement of MBF using a multipinhole dedicated cardiac SPECT camera in a pig model of rest and transient occlusion at stress using 3 common tracers: (201)Tl, (99m)Tc-tetrofosmin, and (99m)Tc-sestamibi.

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      Affiliations
      [1 ] Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; and gwells@ottawaheart.ca.
      [2 ] Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; and.
      [3 ] Nordion Inc., Ottawa, Ontario, Canada.
      Journal
      J. Nucl. Med.
      Journal of nuclear medicine : official publication, Society of Nuclear Medicine
      Society of Nuclear Medicine
      1535-5667
      0161-5505
      Oct 2014
      : 55
      : 10
      25189340
      jnumed.114.139782
      10.2967/jnumed.114.139782
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