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Dynamic SPECT measurement of absolute myocardial blood flow in a porcine model.
R Glenn Wells
1 ,
Rachel Timmins
2 ,
Ran Klein
2 ,
Julia Lockwood
2 ,
Brian Marvin
2 ,
Robert A deKemp
2 ,
Lihui Wei
3 ,
Terrence D Ruddy
2
Oct 2014
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Abstract
Absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) provide incremental diagnostic and prognostic information over relative perfusion alone. Recent development of dedicated cardiac SPECT cameras with better sensitivity and temporal resolution make dynamic SPECT imaging more practical. In this study, we evaluate the measurement of MBF using a multipinhole dedicated cardiac SPECT camera in a pig model of rest and transient occlusion at stress using 3 common tracers: (201)Tl, (99m)Tc-tetrofosmin, and (99m)Tc-sestamibi.