Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Decreased Free 1,25-Dihydroxycholecalciferol Index in Patients with the Nephrotic Syndrome

      , , ,

      Nephron

      S. Karger AG

      Nephrotic Syndrome, Calcium, Vitamin D, 1,25-Dihydroxycholecalciferol

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The serum concentrations of calcium, phosphorus, parathyroid hormone, vitamin D<sub>3</sub> metabolites and their transport protein (DBP) were measured in 18 patients with the nephrotic syndrome (mean daily proteinuria 8.8 g). The glomerular filtration rate was normal in 13 patients while the remaining 5 had a mild degree of renal failure. The serum concentrations of total protein, albumin and DBP were significantly decreased in patients with the nephrotic syndrome. The serum calcium concentration was decreased but the calculated ionized calcium concentration remained normal. The serum concentrations of 25-hydroxycholecalciferol (5.3 ± 3.1 μg/l) and 1,25-dihydroxycholecalciferol [1,25-(OH)<sub>2</sub>D<sub>3</sub> (20 ± 12 ng/l)] were significantly lower in patients with the nephrotic syndrome and normal glomerular filtration rates than in normal controls (14.4 ± 4 μg/l and 42 ± 13 ng/l, respectively). The free 1,25-(OH)<sub>2</sub>D<sub>3</sub> index was also significantly below normal (0.9 ± 0.4 vs. 1.8 ± 0.4). Total and free 1,25-(OH)<sub>2</sub>D<sub>3</sub> were still further reduced in patients with mild renal failure. The nephrotic syndrome thus results in mild vitamin D depletion with decreased free 1,25-(OH)<sub>2</sub>D<sub>3</sub> concentrations but generally without secondary hyperparathyroidism.

          Related collections

          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1986
          1986
          04 December 2008
          : 42
          : 3
          : 231-235
          Affiliations
          Laboratorium voor Experimentele Geneeskunde en Endocrinologie (Legendo), Leuven, Belgium
          Article
          183672 Nephron 1986;42:231–235
          10.1159/000183672
          3753749
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Comments

          Comment on this article