9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Modification of Source Strength in Low-Dose-Rate Lung Brachytherapy with 125I and 103Pd Seeds

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background:

          A new treatment approach for most patients who have undergone early stage non-small-cell lung carcinoma (NSCLC) is wedge resection plus permanent implant brachytherapy. However, the specification of dose to medium at low energies especially in heterogeneous lung is unclear yet.

          Objective:

          The present study aims to modify source strength for different configurations of 125I and 103Pd seeds used in lung permanent implant brachytherapy.

          Methods:

          Different arrays of 125I and 103Pd seeds were simulated by MCNPX code in protocol-based water vs. actual 3D lung environments. Absorbed dose was, then, scored in both mediums. Dose differences between both environments were calculated and source strength was modified for the prescription point. In addition, lung-to-water absorbed dose ratio was obtained and presented by precise equations.

          Results:

          Due to significant differences in prescription dose, source strength was modified 16%-19% and 37%-43% for different configurations of 125I and 103Pd seeds, respectively. In addition, depth-dependent dose differences were observed between the actual lung and protocol-based water mediums (dose difference as a function of depth).

          Conclusion:

          Modification of source strength is essential for different arrangements of 125I and 103Pd seeds in lung implantation. Modified source strength and presented equations are recommended to be considered in future studies based on lung brachytherapy.

          Related collections

          Most cited references18

          • Record: found
          • Abstract: found
          • Article: not found

          Supplement to the 2004 update of the AAPM Task Group No. 43 Report.

          Since publication of the 2004 update to the American Association of Physicists in Medicine (AAPM) Task Group No. 43 Report (TG-43U1), several new low-energy photon-emitting brachytherapy sources have become available. Many of these sources have satisfied the AAPM prerequisites for routine clinical use as of January 10, 2005, and are posted on the Joint AAPM/RPC Brachytherapy Seed Registry. Consequently, the AAPM has prepared this supplement to the 2004 AAPM TG-43 update. This paper presents the AAPM-approved consensus datasets for these sources, and includes the following 125I sources: Amersham model 6733, Draximage model LS-1, Implant Sciences model 3500, IBt model 1251L, IsoAid model IAI-125A, Mentor model SL-125/ SH-125, and SourceTech Medical model STM1251. The Best Medical model 2335 103Pd source is also included. While the methodology used to determine these data sets is identical to that published in the AAPM TG-43U1 report, additional information and discussion are presented here on some questions that arose since the publication of the TG-43U1 report. Specifically, details of interpolation and extrapolation methods are described further, new methodologies are recommended, and example calculations are provided. Despite these changes, additions, and clarifications, the overall methodology, the procedures for developing consensus data sets, and the dose calculation formalism largely remain the same as in the TG-43U1 report. Thus, the AAPM recommends that the consensus data sets and resultant source-specific dose-rate distributions included in this supplement be adopted by all end users for clinical treatment planning of low-energy photon-emitting brachytherapy sources. Adoption of these recommendations may result in changes to patient dose calculations, and these changes should be carefully evaluated and reviewed with the radiation oncologist prior to implementation of the current protocol.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Radiation pneumonitis following large single dose irradiation: a re-evaluation based on absolute dose to lung.

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Determination of Absorbed Dose in a Patient Irradiated by Beams of X or Gamma Rays in Radiotherapy Procedures

                Bookmark

                Author and article information

                Journal
                J Biomed Phys Eng
                J Biomed Phys Eng
                Journal of Biomedical Physics & Engineering
                Journal of Biomedical Physics and Engineering (Iran )
                2251-7200
                September 2017
                01 September 2017
                : 7
                : 3
                : 191-204
                Affiliations
                [1 ]Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
                [2 ]Department of Biomedical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
                [3 ]Advanced Health Technologies Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
                Author notes
                *Corresponding author:H. Mostaghimi, Department of Biomedical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Advanced Health Technologies Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
                Article
                JBPE-7-3
                5654126
                4f7fb115-4619-41a4-8364-9614dec41f60
                Copyright: © Journal of Biomedical Physics and Engineering

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 27 June 2017
                : 10 May 2017
                Categories
                Original Article

                125i seed ,103pd seed , lung permanent implant brachytherapy , monte carlo method

                Comments

                Comment on this article