Zhiqiang Zheng:
ORCID: http://orcid.org/0000-0003-1028-3246
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – original draftRole: Writing – review & editing
Ching Wooen Sze: Role: Formal analysisRole: InvestigationRole: Methodology
Choong Tat Keng: Role: Formal analysisRole: InvestigationRole: Methodology
Muthafar Al-Haddawi: Role: Formal analysisRole: Writing – original draft
Min Liu: Role: Investigation
Sue Yee Tan: Role: Investigation
Hwee Ling Kwek: Role: Investigation
Zhisheng Her: Role: Formal analysisRole: InvestigationRole: Methodology
Xue Ying Chan: Role: Investigation
Bhaskar Barnwal: Role: Formal analysisRole: InvestigationRole: Methodology
Eva Loh: Role: Resources
Kenneth Tou En Chang: Role: Resources
Thiam Chye Tan: Role: Resources
Yee-Joo Tan: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole:
Writing – original draftRole: Writing – review & editing
Qingfeng Chen: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole:
Writing – original draftRole: Writing – review & editing
Ratna B. Ray: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
8
September
2017
Publication date Collection: 2017
Volume: 12
Issue: 9
Electronic Location Identifier: e0184127
Affiliations
[1
]
Institute of Molecular and Cell Biology, Singapore, Singapore
[2
]
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National
University Health System, National University of Singapore, Singapore, Singapore
[3
]
Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital,
Singapore, Singapore
[4
]
Duke-NUS Graduate Medical School, Singapore, Singapore
[5
]
Department of Obstetrics & Gynaecology, KK Women's and Children's Hospital, Singapore,
Singapore
[6
]
Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated
Hospital of Guangzhou Medical University, Guangzhou, China
Saint Louis University, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-17-23002
DOI: 10.1371/journal.pone.0184127
PMC ID: 5590885
PubMed ID: 28886065
SO-VID: 4fa33186-6108-4d0c-aba2-729922ea4292
Copyright © © 2017 Zheng et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
“This study was supported by Joint Council Office Development Programme 1334k00082,
the Agency for Science, Technology and Research (A*STAR), Singapore. Qingfeng Chen
is also supported by National Research Foundation Fellowship Singapore NRF-NRFF2017-03.
The funders had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Liver Diseases
Subject:
Fatty Liver
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Adenomas
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Liver Diseases
Subject:
Liver Fibrosis
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Hepatocytes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Liver
Subject:
Hepatocytes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Liver
Subject:
Hepatocytes