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      We’ve Come a Long Way, Baby: Announcing a Special Issue to Commemorate the Publication of Molecule’s 20,000th Paper

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          Abstract

          We’ve Come a Long Way, Baby Title song of the 1979 album of the same name by American country-music composer and singer Loretta Lynn On behalf of my Section Editor-in-Chief co-author colleagues I am pleased to announce a Special Issue to commemorate the recent publication of Molecules’ 20,000th paper. For this we invite the submission of high quality reviews and articles on any of the subjects covered in Molecules’ eighteen topical sections. While a country-western song title may seem out of place in a Molecules Editorial, the words nevertheless seem most appropriate to define the journal’s trajectory since volume 1 was published in 1996, to the occasion we now aim to celebrate with the Special Issue being announced herein. Between Chattopadhyay et al.’s Synthesis of the Demospongic Compounds, (6Z,11Z)-Octa-decadienoic Acid and (6Z,11Z)-Eicosadienoic Acid [1], the first non-editorial paper published in what was then one of the first e-journals in the field, to the paper we now celebrate, Cagide et al.’s Optimizing the Synthetic Route of Chromone-2-carboxylic Acids: A Step forward to Speed-up the Discovery of Chromone-based Multitarget-directed Ligands [2], Molecules and its publisher MDPI AG have indeed come a very long way in a very short time [3] and much has happened in these 23 plus years, during which our growth has been nothing short of spectacular, as witnessed by Figure 1, which shows the years some of our milestone papers were published. Molecules is now one of the preeminent Open Access journals in the field of chemistry, with a 2018 Journal Citation Report® Impact Factor of 3.060 and a 5-Year Impact Factor of 3.380 (2018) [4]. It ranks 68/172 (Q2) in the category “Chemistry, Multidisciplinary” and 136/298 (Q2) in “Biochemistry and Molecular Biology.” MDPI AG’s trajectory over these years has been even more spectacular [5], but perhaps only one number will suffice to illustrate this: Molecules now has 213 sibling journals. As for the mechanics of this Special Issue, we anticipate a 90-day submission period, following the normal submission process, during which the Section Editors and I will be selecting the manuscripts that move on to standard anonymous peer review. To encourage publication of high quality papers, and submissions on underrepresented topics or from underserved regions, each Section Editor will have access to a certain number of page charge waivers, to be used at their discretion. In summary, we would like to invite all chemists and scientists working in related areas to submit their best work to this Special Issue, as well as to Molecules.

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          Optimizing the Synthetic Route of Chromone-2-carboxylic Acids: A Step forward to Speed-up the Discovery of Chromone-based Multitarget-directed Ligands

          6-Bromochromone-2-carboxylic acid (3) was synthesized by a microwave-assisted process. The optimization of the reaction was performed varying parameters, such as type of base/number of reagent equivalents, solvent, temperature and reaction time. The yield of the reaction was improved to 87%. The new synthetic route is versatile as several chromone-2-carboxylic acids (compounds 4B–10B) were obtained with good yields (54–93%). Only in the case of the nitro substituent (compound 11B), an ester was obtained instead of the desired carboxylic acid. Following this synthetic route chromone carboxylic acids can be attained with a high degree of purity, without the need of the tedious and expensive purification processes through column chromatography. The reaction is safe, cost-effective, fast and robust, and can be used in the development of concise and diversity-oriented libraries based on chromone scaffold. The overall study can be looked as a step forward to speed-up the discovery of chromone-based multitarget-directed ligands.
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            Synthesis of the Demospongic Compounds, (6Z, 11Z)-Octadecadienoic Acid and (6Z, 11Z)-Eicosadienoic Acid

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                Author and article information

                Journal
                Molecules
                Molecules
                molecules
                Molecules
                MDPI
                1420-3049
                31 December 2019
                January 2020
                : 25
                : 1
                : 173
                Affiliations
                [1 ] Molecules Green Chemistry Section Editor-in-Chief
                [2 ] Molecules Organic Chemistry Section Editor-in-Chief
                [3 ] Molecules Organometallic Chemistry Section Editor-in-Chief
                [4 ] Molecules Theoretical Chemistry Section Editor-in-Chief
                [5 ] Molecules Editor-in-Chief
                [6 ] Molecules Medicinal Chemistry Section Editor-in-Chief
                [7 ] Molecules Analytical Chemistry Section Editor-in-Chief
                [8 ] Molecules Natural Products Chemistry Section Editor-in-Chief
                [9 ] Molecules Organic Chemistry Section Editor-in-Chief
                [10 ] Molecules Bioorganic Chemistry Section Editor-in-Chief
                Article
                molecules-25-00173
                10.3390/molecules25010173
                6983236
                31906207
                4fbab739-eccd-497d-a3de-81262c2e7098
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 30 December 2019
                : 30 December 2019
                Categories
                Editorial

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