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Procalcitonin in the context of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.
Michael Veldeman
1 ,
Daniel Lepore
2
,
3 ,
Anke Höllig
1 ,
Hans Clusmann
1 ,
Christian Stoppe
2 ,
Gerrit Alexander Schubert
1 ,
Walid Albanna
1
Sep 04 2020
AUC = area under the curve,
CRP = C-reactive protein,
DCI = delayed cerebral ischemia,
EBI = early brain injury,
GOSE = Glasgow Outcome Scale–Extended,
HH = Hunt and Hess,
IL = interleukin,
PCT = procalcitonin,
ROC = receiver operating characteristic,
SE = standard error,
SIRS = systemic inflammatory response syndrome,
UTI = urinary tract infection,
aSAH = aneurysmal subarachnoid hemorrhage,
cerebral aneurysm,
delayed cerebral ischemia,
noDCI = subgroup of aSAH patients without DCI,
procalcitonin,
subarachnoid hemorrhage,
vascular disorders
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Abstract
Aneurysmal subarachnoid hemorrhage (aSAH) initiates a deleterious cascade activating multiple inflammatory processes, which can contribute to delayed cerebral ischemia (DCI). Procalcitonin (PCT) is an established marker for sepsis treatment monitoring, and its time course in the context of DCI after aSAH remains unclear. The aim of this trial was to assess the predictive and confirmative value of PCT levels in the context of DCI.
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Author and article information
AUC = area under the curve,CRP = C-reactive protein,DCI = delayed cerebral ischemia,EBI = early brain injury,GOSE = Glasgow Outcome Scale–Extended,HH = Hunt and Hess,IL = interleukin,PCT = procalcitonin,ROC = receiver operating characteristic,SE = standard error,SIRS = systemic inflammatory response syndrome,UTI = urinary tract infection,aSAH = aneurysmal subarachnoid hemorrhage,cerebral aneurysm,delayed cerebral ischemia,noDCI = subgroup of aSAH patients without DCI,procalcitonin,subarachnoid hemorrhage,vascular disorders
AUC = area under the curve, CRP = C-reactive protein, DCI = delayed cerebral ischemia, EBI = early brain injury, GOSE = Glasgow Outcome Scale–Extended, HH = Hunt and Hess, IL = interleukin, PCT = procalcitonin, ROC = receiver operating characteristic, SE = standard error, SIRS = systemic inflammatory response syndrome, UTI = urinary tract infection, aSAH = aneurysmal subarachnoid hemorrhage, cerebral aneurysm, delayed cerebral ischemia, noDCI = subgroup of aSAH patients without DCI, procalcitonin, subarachnoid hemorrhage, vascular disorders