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      Acute effects of single‐dose aripiprazole and haloperidol on resting cerebral blood flow (rCBF) in the human brain†

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          Abstract

          Antipsychotic drugs act on the dopaminergic system (first‐generation antipsychotics, FGA), but some also directly affect serotonergic function (second‐generation antipsychotics, SGA) in the brain. Short and long‐term effects of these drugs on brain physiology remain poorly understood. Moreover, it remains unclear whether any physiological effect in the brain may be different for FGAs and SGAs. Immediate (+3.30 h) and different effects of single‐dose FGA (haloperidol, 3 mg) and a SGA (aripiprazole, 10 mg) on resting cerebral blood flow (rCBF) were explored in the same 20 healthy volunteers using a pulsed continuous arterial spin labeling (pCASL) sequence (1.5T) in a placebo‐controlled, repeated measures design. Both antipsychotics increased striatal rCBF but the effect was greater after haloperidol. Both decreased frontal rCBF, and opposite effects of the drugs were observed in the temporal cortex (haloperidol decreased, aripiprazole increased rCBF) and in the posterior cingulate (haloperidol increased, aripiprazole decreased rCBF). Further increases were evident in the insula, hippocampus, and anterior cingulate after both antipsychotics, in the motor cortex following haloperidol and in the occipital lobe the claustrum and the cerebellum after aripiprazole. Further decreases were observed in the parietal and occipital cortices after aripiprazole. This study suggests that early and different rCBF changes are evident following a single‐dose of FGA and SGA. The effects occur in healthy volunteers, thus may be independent from any underlying pathology, and in the same regions identified as structurally and functionally altered in schizophrenia, suggesting a possible relationship between antipsychotic‐induced rCBF changes and brain alterations in schizophrenia. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.

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          Author and article information

          Contributors
          rowena.handley@kcl.ac.uk
          Journal
          Hum Brain Mapp
          Hum Brain Mapp
          10.1002/(ISSN)1097-0193
          HBM
          Human Brain Mapping
          Wiley Subscription Services, Inc., A Wiley Company (Hoboken )
          1065-9471
          1097-0193
          February 2013
          25 March 2012
          : 34
          : 2 ( doiID: 10.1002/hbm.v34.2 )
          : 272-282
          Affiliations
          [ 1 ]Department of Psychosis Studies, King's College London, Institute of Psychiatry, United Kingdom
          [ 2 ]Department of Neuroimaging, King's College London, Institute of Psychiatry, United Kingdom
          [ 3 ]Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
          [ 4 ]BCN Neuroimaging Center, University of Groningen, Groningen, The Netherlands
          [ 5 ]University Children's Hospital, Zurich, Switzerland
          [ 6 ]Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
          [ 7 ]Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom
          [ 8 ]Department of Psychological Medicine, Perinatal Psychiatry & Stress, King's College London, Institute of Psychiatry, United Kingdom
          [ 9 ]NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust, London, United Kingdom
          Author notes
          [*] [* ]Department of Psychosis Studies, King's College London, Institute of Psychiatry, PO40, 16 De Crespigny Park, London, SE5 8AF, UK
          Article
          PMC6870199 PMC6870199 6870199 HBM21436
          10.1002/hbm.21436
          6870199
          22451196
          4fbcb94e-4551-47da-80b0-9f3f7df61c37
          Copyright © 2012 Wiley Periodicals, Inc.
          History
          : 21 January 2011
          : 22 June 2011
          : 25 July 2011
          Page count
          Figures: 5, Tables: 1, References: 61, Pages: 11, Words: 9523
          Funding
          Funded by: American Psychiatric Institute for Research and Education (APIRE) and the NIHR Biomedical Research Centre for Mental Health, South London
          Funded by: Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College, London
          Funded by: GE Healthcare and Merck & Co. (to D.C.A.)
          Categories
          Research Article
          Research Articles
          Custom metadata
          2.0
          February 2013
          Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.2 mode:remove_FC converted:15.11.2019

          haloperidol,arterial spin labeling,resting blood flow,aripiprazole,antipsychotics

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