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      Rosuvastatin pretreatment suppresses distant organ injury following unilateral renal ischemia-reperfusion in hypertensive Dahl salt-sensitive rats.

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          Abstract

          Ischaemia-reperfusion (I/R) induces distant organ injury (DOI) via inflammation and oxidative stress. Statins have anti-inflammatory and anti-oxidant effects independent of their cholesterol-lowering properties. To clarify whether statins could suppress DOI, we investigated the effect of rosuvastatin (RO) on the contralateral kidney following unilateral renal I/R.

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          Author and article information

          Journal
          Nephrology (Carlton)
          Nephrology (Carlton, Vic.)
          Wiley
          1440-1797
          1320-5358
          Nov 2018
          : 23
          : 11
          Affiliations
          [1 ] Department of Nephrology and Hypertension, Fukushima Medical University School of Medicine, Fukushima, Japan.
          [2 ] Division of Clinical Research, Center for Advanced and Integrated Renal Science (CAIRS), Tohoku University Graduate School of Medicine, Sendai, Japan.
          Article
          10.1111/nep.13169
          28940950
          4fc5a912-0618-4be3-ac13-8a18a0f8126c
          © 2017 Asian Pacific Society of Nephrology.
          History

          distant organ injury,oxidative stress,renal ischemia reperfusion,rosuvastatin,superoxide dismutase

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