The effect of fatigue damage (FD) on the energy absorption properties of precompressed honeycomb paperboard is investigated by fatigue compression experiments. The constitutive relations of honeycomb paperboard have been changed after the fatigue damage. The results show that FD has effect on plateau stress and energy absorption capacity of honeycomb paperboard after fatigue cycles but has no significant effect on densification strain. Energy absorption diagram based on the effect of FD is constructed from the stress-strain curves obtained after fatigue compression experiments. FD is a significant consideration for honeycomb paperboard after transports. The results of this paper could be used for optimization design of packaging materials.