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      Synthesis and characterization of collagen-chitosan-hydroxyapatite artificial bone matrix.

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          Abstract

          In this study, a new artificial bone matrix was constructed with collagen and Ca(5)(PO(4))(3)OH (hydroxyapatite/HA) which are the main components of natural bone. To improve the property of the artificial bone matrix, chitosan (CS), a kind of positive charged polysaccharide, was crosslinked into the scaffolds. Solid-liquid phase separation method was used to shape 3D porous structure benefited for cells growing into. The artificial bone matrix was investigated by transmission electron microscopy, scanning electron microscopy, and electron spectroscopy for chemical analysis, etc. for structures and characteristics. And its ability of bone repair was investigated by orthotope bone defect reparation in vivo. The results showed that the artificial bone matrix was a porousscaffold with three-dimension interconnected fiber microstructure. HA particles were dispersed evenly among collagen fiber and CS was modified on the surface of collagen fiber. It was indicated that this artificial bone matrix could be used as a bone substitute with outstanding properties.

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          Author and article information

          Journal
          J Biomed Mater Res A
          Journal of biomedical materials research. Part A
          Wiley
          1552-4965
          1549-3296
          Jul 2008
          : 86
          : 1
          Affiliations
          [1 ] Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, People's Republic of China.
          Article
          10.1002/jbm.a.31758
          18080313
          4fede43a-69fe-45e6-90d8-68391fc9f078
          History

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