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      Factors Involved in the Development of Hypertension Induced by a Low-Protein Diet in Rats with Renal Injury

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          Abstract

          Background/Aims: While a low-protein diet (LPD) has been reported to increase blood pressure, the mechanism for its increase has not yet been clarified. We investigated the factors involved in the development of hypertension induced by LPD in rats with post-cyclosporine (CsA) nephropathy, and determined the appropriate composition for LPD that is to be utilized for renal research. Methods: The rats were divided into 4 groups, each group being fed either a normal-protein diet (NPD), LPD with a low sucrose content as the main component of carbohydrate, LPD with a high-sucrose content, or LPD with low sucrose plus 2% L-arginine (Arg) for 12 weeks, and the blood pressure, urinary nitric oxide (NO) metabolite (NOx) excretion, renal NO-generating capacity and renal Arg content were compared among these groups. CsA was administered for the first 5 weeks to all groups. Results: The blood pressure was significantly higher in the high-sucrose LPD rats than in the NPD and the low-sucrose LPD rats. The supplement of Arg significantly decreased the blood pressure in the low-sucrose LPD rats. Urinary NOx, renal NO-generating capacity and the renal Arg content were significantly lower in the low-sucrose LPD rats than in the NPD rats. Arg supplementation to the LPD rats returned these values to the level of the NPD rats. Conclusion: The increase in blood pressure by LPD was associated with the higher amount of sucrose contained in LPD and the decrease in NO generation caused by the Arg depletion in rats with post-CsA nephropathy. For animal experiments we recommend that sucrose should not be used in LPD to balance the energy intake between LPD and NPD, and that a small amount of Arg be supplemented to LPD.

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          Most cited references 5

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          Dietary protein and blood pressure

           E Obarzanek (1996)
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            Diet-induced changes in sympathoadrenal activity: Implications for thermogenesis

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              Effects of sucrose ingestion on blood pressure

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                Author and article information

                Journal
                KBR
                Kidney Blood Press Res
                10.1159/issn.1420-4096
                Kidney and Blood Pressure Research
                S. Karger AG
                1420-4096
                1423-0143
                2004
                July 2004
                02 February 2004
                : 27
                : 1
                : 1-9
                Affiliations
                Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
                Article
                74525 Kidney Blood Press Res 2004;27:1–9
                10.1159/000074525
                14583657
                © 2004 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 6, Tables: 3, References: 32, Pages: 9
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/74525
                Categories
                Original Paper

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