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      Spontaneous Erythroid Leukemia in a 7-Week-Old Crl:CD (SD) Rat

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          Abstract

          A young male Crl:CD (SD) rat with erythroid leukemia that presented with emaciation, abdominal distension and a pale visible mucosal membrane was euthanized at 7 weeks of age. At necropsy, enlargement of liver, spleen and pancreatic lymph node was noted. Analysis of blood smear samples revealed many mono- or binucleated erythroblasts that had PAS-positive vacuoles in the cytoplasm. Histopathologically, neoplastic proliferation of atypical cells was observed in the hepatic sinusoids, splenic red pulp, bone marrow, pancreatic lymph node, kidney and lung. Neoplastic cells showed a round to spindle shape, and some neoplastic cells had deeply stained small nuclei and small cytoplasms and resembled erythroblasts. Immunohistochemically, many neoplastic cells were positive for hemoglobin. To our knowledge, this is the first report of erythroid leukemia in a rat of this age. The observed features were similar to those of pure erythroid leukemia in humans.

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          Most cited references5

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          The morphology, immunohistochemistry, and incidence of hematopoietic neoplasms in mice and rats.

          Hematopoietic neoplasms in the rodent may be classified into lymphoid or nonlymphoid neoplasms. Lymphoid neoplasms include the following morphologic types: follicular center cell, lymphoblast (lymphocytic), immunoblast, plasma cell, and large granular lymphocyte (LGL). Nonlymphoid hematopoietic neoplasms include histiocytic sarcoma, granulocytic leukemia, erythroid leukemia, and mast cell tumors. Most types of hematopoietic neoplasms, exclusive of LGL lymphoma (leukemia), are more common in mice than in rats. Specific strains of mice have a hematopoietic tumor incidence of more than 50% in aged animals. Some strains of rats (i.e., Fischer-344) may have an incidence of over 50% of LGL lymphoma in aged animals. The tumor type and incidence are characteristic for each rat or mouse strain. Hematopoietic neoplasms have been better characterized immunomorphologically in mice than in rats. The specific cell type and tissue of origin for hematopoietic neoplasms may be important for safety evaluation of chemicals. Specific chemicals may induce specific types of these tumors, which may be the same or different from the spontaneous types. Lymphoid cell neoplasms should not be grouped with nonlymphoid neoplasms in determining the toxicity and carcinogenicity of test substances.
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            Pure erythroid leukemia.

            Qin Huang (2004)
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              Spontaneous erythroid leukemia in a 6-wk-old male Crlj:B6C3F1 mouse

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                Author and article information

                Journal
                J Toxicol Pathol
                TOX
                Journal of Toxicologic Pathology
                The Japanese Society of Toxicologic Pathology
                0914-9198
                1881-915X
                June 2010
                30 June 2010
                : 23
                : 2
                : 91-94
                Affiliations
                [1 ]Developmental Research Laboratories, Shionogi & Co., Ltd., 3–1–1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan
                Author notes
                Mailing address: Emi Yamamoto, Developmental Research Laboratories, Shionogi & Co., Ltd., 3–1–1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan TEL: 81-6-6331-8081 FAX: 81-6-6332-6385 E-mail: emi.yamamoto@ 123456shionogi.co.jp
                Article
                0549
                10.1293/tox.23.91
                3234639
                22272017
                500dde64-d07c-4edf-9bad-d92d9077e07f
                2010 The Japanese Society of Toxicologic Pathology

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

                History
                : 22 October 2009
                : 01 December 2009
                Categories
                Case Report

                Pathology
                crl:cd (sd) rat,erythroid leukemia,spontaneous
                Pathology
                crl:cd (sd) rat, erythroid leukemia, spontaneous

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