10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension.

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Abstract

Long-term safety and efficacy of osteoporosis treatment are important because of the chronic nature of the disease. We aimed to assess the long-term safety and efficacy of denosumab, which is widely used for the treatment of postmenopausal women with osteoporosis.

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Journal

Journal ID (iso-abbrev): Lancet Diabetes Endocrinol

Title: The lancet. Diabetes & endocrinology

Publisher: Elsevier BV

ISSN (Electronic): 2213-8595

ISSN (Print): 2213-8587

Publication date (Electronic): May 22 2017

Affiliations

[1 ] Michigan Bone and Mineral Clinic, Detroit, MI, USA; Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Harbor, MI, USA. Electronic address: hgbone.md@att.net.

[2 ] Research and Development, Amgen, Thousand Oaks, CA, USA.

[3 ] Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

[4 ] Department of Medicine, Laval University and CHU de Québec Research Centre, Quebec City, QC, Canada.

[5 ] INSERM UMR 1033, Université de Lyon, Hôpital Edouard Herriot, Lyon, France.

[6 ] San Francisco Coordinating Center, CPMC Research Institute, UCSF, San Francisco, CA, USA.

[7 ] Krakow Medical Centre, Krakow, Poland.

[8 ] Department of Endocrinology and Metabolism, Medical University Graz, Graz, Austria.

[9 ] Department of Medicine, Division of Endocrinology, University of British Columbia, Vancouver, BC, Canada.

[10 ] Department of Osteoporosis, Bern University Hospital, Bern, Switzerland.

[11 ] Bone and Cartilage Metabolism Unit, University of Liège, Liège, Belgium.

[12 ] Department of Rheumatology, Paris Descartes University, Paris, France.

[13 ] Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

[14 ] Department of Pathology and Cell Biology, Columbia University, New York, NY, USA; Regional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, USA.

[15 ] Center for Bone Quality, Leiden University Medical Center, Leiden, Netherlands.

Article

Publisher Item ID: S2213-8587(17)30138-9

DOI: 10.1016/S2213-8587(17)30138-9

PubMed ID: 28546097

SO-VID: 501366a2-8696-4e2f-873c-1de416c6e8c5

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