Possible Role of Alpha-2-Noradrenergic Receptors in Modulation of Sexual Behavior in Female Guinea Pigs

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Abstract

These studies examine whether αi-noradrenergic receptor stimulation alone is sufficient to facilitate lordosis behavior in ovariectomized, estrogen-primed female guinea pigs and to what extent α2-noradrenergic receptors are involved in this steroid-dependent behavior. Neither of the α1-agonists, phenylephrine or methoxamine, significantly facilitated lordosis in ovariectomized females primed with 10 µg of estradiol benzoate for 1 or 3 days. Animals exhibiting estrogen plus clonidine-facilitated lordosis showed a decrease in the behavior when given one of two α2-antagonists (yohimbine or idazoxan). Idazoxan also attenuated lordosis in animals given estrogen plus progesterone. These findings, in combination with previous findings (that specific α1-antagonists block lordosis), suggest that α2-receptors, in addition to α1-receptors play a role in modulation of lordosis behavior.

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Author and article information

Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1987

Publication date (Print): 1987

Publication date (Electronic): 02 April 2008

Volume: 46

Issue: 1

Pages: 10-13

Affiliations

Institute of Animal Behavior and Department of Biological Sciences, Rutgers University, Newark, N.J., USA

Article

Publisher ID: 124790 Other ID: Neuroendocrinology 1987;46:10–13

DOI: 10.1159/000124790

PubMed ID: 2886935

SO-VID: 5022cd28-cd56-41d4-9d90-7c86685321f8

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 04 August 1986

Date accepted : 10 December 1986

Page count

Pages: 4

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