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      Possible Role of Alpha-2-Noradrenergic Receptors in Modulation of Sexual Behavior in Female Guinea Pigs

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          Abstract

          These studies examine whether αi-noradrenergic receptor stimulation alone is sufficient to facilitate lordosis behavior in ovariectomized, estrogen-primed female guinea pigs and to what extent α<sub>2</sub>-noradrenergic receptors are involved in this steroid-dependent behavior. Neither of the α<sub>1</sub>-agonists, phenylephrine or methoxamine, significantly facilitated lordosis in ovariectomized females primed with 10 µg of estradiol benzoate for 1 or 3 days. Animals exhibiting estrogen plus clonidine-facilitated lordosis showed a decrease in the behavior when given one of two α<sub>2</sub>-antagonists (yohimbine or idazoxan). Idazoxan also attenuated lordosis in animals given estrogen plus progesterone. These findings, in combination with previous findings (that specific α<sub>1</sub>-antagonists block lordosis), suggest that α<sub>2</sub>-receptors, in addition to α<sub>1</sub>-receptors play a role in modulation of lordosis behavior.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1987
          1987
          02 April 2008
          : 46
          : 1
          : 10-13
          Affiliations
          Institute of Animal Behavior and Department of Biological Sciences, Rutgers University, Newark, N.J., USA
          Article
          124790 Neuroendocrinology 1987;46:10–13
          10.1159/000124790
          2886935
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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