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      Developmental Sex Differences in Estrogen Receptor-β mRNA Expression in the Mouse Hypothalamus/Preoptic Region

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          Abstract

          Estrogens play a significant role during mammalian brain development and are required for the masculinization of neuronal circuits involved in sex-specific behaviors and neuroendocrine functions. Cellular estrogen signalling is transmitted through nuclear estrogen receptors (ER) which are divided into two subforms: the ER-α as well as the recently cloned ER-β have been demonstrated in the hypothalamus. In the present study, we have analyzed the sex-specific expression of ER-β mRNA in the pre- and postnatal mouse hypothalamus/preoptic region (Hyp/POA) by semiquantitative RT-PCR. The ER-β mRNA was detectable as early as embryonic day (E) 15 in the diencephalon of both sexes. In males, levels of mRNA expression in the Hyp/POA increased until birth and remained high throughtout postnatal (P) development, whereas in females, such an increase was not observed. Significantly higher mRNA levels were detected in the male Hyp/POA from E17 until P15. Perinatal sex differences in ER-β mRNA expression coincide with higher estrogen-forming rates in the male Hyp/POA. At present, no direct evidence is available which demonstrates that estrogen signalling through ER-β is involved in brain development. However, data from our and other studies suggest a potential role for this signal transduction pathway for brain differentiation.

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          Most cited references 8

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          Cloning of a novel receptor expressed in rat prostate and ovary.

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            Comparative distribution of estrogen receptor-? and -? mRNA in the rat central nervous system

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              Differential Ligand Activation of Estrogen Receptors ER and ER at AP1 Sites

               K Paech (1997)
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                Author and article information

                Journal
                NEN
                Neuroendocrinology
                10.1159/issn.0028-3835
                Neuroendocrinology
                S. Karger AG
                0028-3835
                1423-0194
                1998
                October 1998
                14 October 1998
                : 68
                : 4
                : 229-234
                Affiliations
                Abteilung Anatomie und Zellbiologie, Universität Ulm, Germany
                Article
                54370 Neuroendocrinology 1998;68:229–234
                10.1159/000054370
                9772337
                © 1998 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 3, References: 22, Pages: 6
                Categories
                Reproductive Neuroendocrinology

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