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Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease.
Benedikt Fritzsching
1 ,
Zhe Zhou-Suckow ,
Joanna B Trojanek ,
Susanne C Schubert ,
Jolanthe Schatterny ,
Stephanie Hirtz ,
Raman Agrawal ,
Thomas Muley ,
Nicolas Kahn ,
Carsten Sticht ,
Nikolas Gunkel ,
Tobias Welte ,
Scott H Randell ,
Florian Länger ,
Philipp Schnabel ,
Felix J F Herth ,
Marcus A Mall
Apr 15 2015
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Abstract
In many organs, hypoxic cell death triggers sterile neutrophilic inflammation via IL-1R signaling. Although hypoxia is common in airways from patients with cystic fibrosis (CF), its role in neutrophilic inflammation remains unknown. We recently demonstrated that hypoxic epithelial necrosis caused by airway mucus obstruction precedes neutrophilic inflammation in Scnn1b-transgenic (Scnn1b-Tg) mice with CF-like lung disease.