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      In utero programming of chronic disease.

      Clinical Science (London, England : 1979)

      Prenatal Exposure Delayed Effects, Pregnancy, metabolism, Placental Insufficiency, Middle Aged, Male, Infant, Newborn, etiology, Hypertension, Humans, Fetal Growth Retardation, Female, physiology, Embryonic and Fetal Development, Diabetes Mellitus, Type 2, Coronary Disease, Chronic Disease, Child, Preschool, Child

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          Abstract

          1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they permanently change their structure and metabolism. 2. These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension. 3. This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.

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          9680492

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