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      HLA-DR2 Antigen Linkage in Patients with Apical Hypertrophic Cardiomyopathy in Japan

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          Abstract

          Apical hypertrophic cardiomyopathy, a very common disorder in Japan, is characterized by giant negative T waves on the electrocardiogram and abnormal apical hypertrophy on the ventriculogram. This histocompatibility complexes (HLA-A, -B, -C, -DR) of 20 unrelated patients with apical hypertrophic cardiomyopathy (18 male, 2 female) were examined. There was no significant difference in the frequency of HLA-A, -B, -C antigens between patients and controls (n = 100). However, HLA-DR 2 was more frequent in patients with apical hypertrophic cardiomyopathy (65.0%) than controls (33.0%) (p < 0.01). We conclude that apical hypertrophic cardiomyopathy might be associated with genes in the HLA-DR region and that genetic factors linked to HLA play a role in the pathogenesis of this disease.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1996
          1996
          19 November 2008
          : 87
          : 6
          : 488-491
          Affiliations
          aSecond Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, bHimekawa Hospital, cKyoto Red Cross Blood Center, and dOhtsu Red Cross Hospital, Japan
          Article
          177143 Cardiology 1996;87:488–491
          10.1159/000177143
          8904675
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          General Cardiology

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