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      Effects of hCG on Serum Levels of Testosterone, Dihydrotestosterone and Androstenedione in Male Mice

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          Abstract

          The concentrations of testosterone (T), 5α-dihydrotestosterone (5α-DHT) and Δ<sup>4</sup>-androstenedione (Δ<sup>4</sup>A) in the circulating blood were increased by a single subcutaneous injection of 10 IU of hCG in the mouse. The response of androgen synthesis to hCG stimulation was rapid and persisted over a period of 96 h. The increased supply of T to the peripheral organ(s) under the stimulation of hCG might contribute to an increase in circulating 5α-DHT. However, the changes in T/5α-DHT ratio implies that the stimulation of T and 5α-DHT production by hCG were not of the same degree.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1978
          1978
          25 November 2008
          : 9
          : 3
          : 169-175
          Affiliations
          Worcester Foundation for Experimental Biology, Shrewsbury, Mass.
          Article
          178910 Horm Res 1978;9:169–175
          10.1159/000178910
          640581
          © 1978 S. Karger AG, Basel

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          Pages: 7
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