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      Extracellular calcium sensing and signalling.

      Nature reviews. Molecular cell biology

      metabolism, genetics, Receptors, Cell Surface, Humans, Calcium-Binding Proteins, physiology, Calcium Signaling, Calcium Channels, Calcium, Animals

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          Abstract

          Ca2+ is well established as an intracellular second messenger. However, the molecular identification of a detector for extracellular Ca2+--the extracellular calcium-sensing receptor--has opened up the possibility that Ca2+ might also function as a messenger outside cells. Information about the local extracellular Ca2+ concentration is conveyed to the interior of many cell types through this unique G-protein-coupled receptor. Here, we describe new emerging concepts concerning the signalling function of extracellular Ca2+, with particular emphasis on the extracellular calcium-sensing receptor.

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          Journal
          10.1038/nrm1154
          12838336

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