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      Parathyroid Hormone-Related Protein as a Renal Regulating Factor

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          Parathyroid hormone (PTH) and PTH-related protein (PTHrP) produce similar biological effects through the PTH/PTHrP receptor. Less is known about the physiological role of PTHrP, which was first identified as the agent of the humoral hypercalcemia of malignancy. Despite the widespread production of PTHrP in healthy individuals, the concentration of the protein is below the detectable limit of current assays, suggesting that PTHrP normally functions locally in an autocrine or paracrine manner. Thus, some differences in their biological activities have been described and they may be related to the presence of different receptors. In this regard, a second receptor that binds selectively to PTH has also been found. Recent studies have demonstrated the expression of both PTH/PTHrP receptor and protein in the renal glomeruli. Moreover, there are convincing data that support a direct role of PTH and PTHrP in modulating renal blood flow and glomerular filtration rate. This multifunctional protein, PTHrP, also has a proliferative effect on both glomerular mesangial cells and tubular epithelial cells. Increases in the expression of PTHrP have been observed in several experimental models of nephropathies, suggesting that PTHrP upregulation is a common event associated with the mechanism of renal injury and repair.

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          Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.

          We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.
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            Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger RNA in human kidney and bone cells

             A. S. Jobert (1996)

              Author and article information

              Am J Nephrol
              American Journal of Nephrology
              S. Karger AG
              June 2001
              25 June 2001
              : 21
              : 3
              : 179-184
              aBone and Mineral Metabolism Laboratory, Research Unit, Fundación Jiménez Díaz, Madrid, bDepartment of Nephrology, Fundació Puigvert, Barcelona, and cDepartment of Physiology, Alcalá School of Medicine, Alcalá de Henares, Spain
              46244 Am J Nephrol 2001;21:179–184
              © 2001 S. Karger AG, Basel

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              Page count
              Tables: 1, References: 40, Pages: 6
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/46244
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