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Chitosan in nasal delivery systems for therapeutic drugs
Author(s):
Luca Casettari
,
Lisbeth Illum
Publication date
Created:
September 2014
Publication date
(Print):
September 2014
Journal:
Journal of Controlled Release
Publisher:
Elsevier BV
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Abstract
There is an obvious need for efficient and safe nasal absorption enhancers for the development of therapeutically efficacious nasal products for small hydrophilic drugs, peptides, proteins, nucleic acids and polysaccharides, which do not easily cross mucosal membranes, including the nasal. Recent years have seen the development of a range of nasal absorption enhancer systems such as CriticalSorb (based on Solutol HS15) (Critical Pharmaceuticals Ltd), Chisys based on chitosan (Archimedes Pharma Ltd) and Intravail based on alkylsaccharides (Aegis Therapeutics Inc.), that is presently being tested in clinical trials for a range of drugs. So far, none of these absorption enhancers have been used in a marketed nasal product. The present review discusses the evaluation of chitosan and chitosan derivatives as nasal absorption enhancers, for a range of drugs and in a range of formulations such as solutions, gels and nanoparticles and finds that chitosan and its derivatives are able to efficiently improve the nasal bioavailability. The revirtew also questions whether chitosan nanoparticles for systemic drug delivery provide any real improvement over simpler chitosan formulations. Furthermore, the review also evaluates the use of chitosan formulations for the improvement of transport of drugs directly from the nasal cavity to the brain, based on its mucoadhesive characteristics and its ability to open tight junctions in the olfactory and respiratory epithelia. It is found that the use of chitosan nanoparticles greatly increases the transport of drugs from nose to brain over and above the effect of simpler chitosan formulations. Copyright © 2014 Elsevier B.V. All rights reserved.
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RNA drug delivery
Author and article information
Journal
Title:
Journal of Controlled Release
Abbreviated Title:
Journal of Controlled Release
Publisher:
Elsevier BV
ISSN (Print):
01683659
Publication date Created:
September 2014
Publication date (Print):
September 2014
Volume
: 190
Pages
: 189-200
Article
DOI:
10.1016/j.jconrel.2014.05.003
PubMed ID:
24818769
SO-VID:
507e23f9-c8f5-4c56-af4e-74378e320ce6
Copyright ©
© 2014
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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