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      Relationship of hyperuricemia with mortality in heart failure patients with preserved ejection fraction.

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          Abstract

          Serum uric acid is a predictor of cardiovascular mortality in heart failure with reduced ejection fraction. However, the impact of uric acid on heart failure with preserved ejection fraction (HFpEF) remains unclear. Here, we investigated the association between hyperuricemia and mortality in HFpEF patients. Consecutive 424 patients, who were admitted to our hospital for decompensated heart failure and diagnosed as having HFpEF, were divided into two groups based on presence of hyperuricemia (serum uric acid ≥7 mg/dl or taking antihyperuricemic agents). We compared patient characteristics, echocardiographic data, cardio-ankle vascular index, and cardiopulmonary exercise test findings between the two groups and prospectively followed cardiac and all-cause mortality. Compared with the non-hyperuricemia group (n = 170), the hyperuricemia group (n = 254) had a higher prevalence of hypertension (P = 0.013), diabetes mellitus (P = 0.01), dyslipidemia (P = 0.038), atrial fibrillation (P = 0.001), and use of diuretics (P < 0.001). Cardio-ankle vascular index (8.7 vs. 7.5, P < 0.001) and V̇e/V̇co2 slope (34.9 vs. 31.9, P = 0.02) were also higher. In addition, peak V̇o2 (14.9 vs. 17.9 ml·kg(-1)·min(-1), P < 0.001) was lower. In the follow-up period (mean 897 days), cardiac and all-cause mortalities were significantly higher in those with hyperuricemia (P = 0.006 and P = 0.004, respectively). In the multivariable Cox proportional hazard analyses after adjustment for several confounding factors including chronic kidney disease and use of diuretics, hyperuricemia was an independent predictor of all-cause mortality (hazard ratio 1.98, 95% confidence interval 1.036-3.793, P = 0.039). Hyperuricemia is associated with arterial stiffness, impaired exercise capacity, and high mortality in HFpEF.

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          Author and article information

          Journal
          Am. J. Physiol. Heart Circ. Physiol.
          American journal of physiology. Heart and circulatory physiology
          American Physiological Society
          1522-1539
          0363-6135
          Oct 2015
          : 309
          : 7
          Affiliations
          [1 ] Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan; and.
          [2 ] Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan; and Department of Advanced Cardiac Therapeutics, Fukushima Medical University, Fukushima, Japan yoshihis@fmu.ac.jp.
          [3 ] Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan; and Department of Advanced Cardiac Therapeutics, Fukushima Medical University, Fukushima, Japan.
          Article
          ajpheart.00533.2015
          10.1152/ajpheart.00533.2015
          26297226
          507e7860-9ada-4d85-8821-f90da8b1966d
          History

          heart failure,uric acid,arterial stiffness,diastolic dysfunction,exercise capacity

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