The lncRNA NEAT1 facilitates cell growth and invasion via the miR-211/HMGA2 axis in breast cancer.

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Abstract

Long non-coding RNAs play a significant role in cancer metastasis. Studies have demonstrated that LncRNA NEAT1 promotes cancer progression. We aimed to explore whether NEAT1 regulated growth and invasion in breast cancer cells. We provided evidence that lncRNA NEAT1 was up-regulated in breast cancer cell lines and tissues. NEAT1 promoted invasion through inducing Epithelial-mesenchymal transition (EMT) and NEAT1 played a role in 5-fluorouracil (5-FU) resistance. In addition, we revealed a reciprocal repression between NEAT1 and miR-211. Furthermore, the EMT-inducer HMGA2 was identified as a down-stream target of miR-211. LncRNA NEAT1 induced EMT and 5-FU resistance through the miR-211/HMGA2 axis. Our findings suggest that lncRNA NEAT1 could be a new diagnostic biomarker and therapy target for breast cancer.

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Author and article information

Journal

Journal ID (iso-abbrev): Int. J. Biol. Macromol.

Title: International journal of biological macromolecules

Publisher: Elsevier BV

ISSN (Electronic): 1879-0003

ISSN (Print): 0141-8130

Publication date (Electronic): Dec 2017

Volume: 105

Issue: Pt 1

Affiliations

[1 ] Department of Breast Cancer, Cancer Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address: lxr_xuerui1@163.com.

[2 ] Department of Nuclear Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

[3 ] Department of Pharmacy, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

[4 ] Department of Pathology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

[5 ] Department of Breast Cancer, Zhongshan City People's Hospital, Zhongshan, China.

[6 ] Department of Breast Cancer, Cancer Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

[7 ] Department of Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Article

Publisher Item ID: S0141-8130(17)30587-1

DOI: 10.1016/j.ijbiomac.2017.07.053

PubMed ID: 28720546

SO-VID: 508a9a81-b8e0-4652-818a-0c4b3375c818

History

Keywords: HMGA2,NEAT1,miR-211

Data availability:

Keywords: HMGA2, NEAT1, miR-211

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