Immunogenic cell death in cancer therapy: Present and emerging inducers

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Abstract

In the tumour microenvironment (TME), immunogenic cell death (ICD) plays a major role in stimulating the dysfunctional antitumour immune system. Chronic exposure of damage‐associated molecular patterns (DAMPs) attracts receptors and ligands on dendritic cells (DCs) and activates immature DCs to transition to a mature phenotype, which promotes the processing of phagocytic cargo in DCs and accelerates the engulfment of antigenic components by DCs. Consequently, via antigen presentation, DCs stimulate specific T cell responses that kill more cancer cells. The induction of ICD eventually results in long‐lasting protective antitumour immunity. Through the exploration of ICD inducers, recent studies have shown that there are many novel modalities with the ability to induce immunogenic cancer cell death. In this review, we mainly discussed and summarized the emerging methods for inducing immunogenic cancer cell death. Concepts and molecular mechanisms relevant to antitumour effects of ICD are also briefly discussed.

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Author and article information

Contributors

Zhengdong Cai: caizhengdong@sjtu.edu.cn

Journal

Journal ID (nlm-ta): J Cell Mol Med

Journal ID (iso-abbrev): J. Cell. Mol. Med

Journal ID (doi): 10.1111/(ISSN)1582-4934

Journal ID (publisher-id): JCMM

Title: Journal of Cellular and Molecular Medicine

Publisher: John Wiley and Sons Inc. (Hoboken )

ISSN (Print): 1582-1838

ISSN (Electronic): 1582-4934

Publication date (Electronic): 18 June 2019

Publication date (Print): August 2019

Volume: 23

Issue: 8 ( doiID: 10.1111/jcmm.2019.23.issue-8 )

Pages: 4854-4865

Affiliations

[ ¹ ] Department of Orthopaedics Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China

[ ² ] Fourth Clinical College Xinxiang Medical University Henan China

[ ³ ] Department of Oncology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai PR China

Author notes

[*] [* ] Correspondence

Zhengdong Cai, Department of Orthopaedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road Shanghai; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Email: caizhengdong@ 123456sjtu.edu.cn

Author information

Gangyang Wang https://orcid.org/0000-0003-1560-7684

Article

Publisher ID: JCMM14356

DOI: 10.1111/jcmm.14356

PMC ID: 6653385

PubMed ID: 31210425

SO-VID: 50961996-303a-4911-8de7-136281f99de4

License:

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

History

Date received : 22 January 2019

Date revision received : 07 April 2019

Date accepted : 12 April 2019

Page count

Figures: 3, Tables: 2, Pages: 12, Words: 8443

Funding

Funded by: Shanghai Jiaotong University Translation Medicine Cross Research Fund

Award ID: ZH2018QNA17

Funded by: Shanghai Sailing Program

Award ID: 19YF1440200

Funded by: National Natural Science Foundation of China

Award ID: 81202115

Funded by: Doctoral Innovation Fund of Shanghai Jiaotong University School of Medicine

Award ID: BXJ201732

Custom metadata

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component-id jcmm14356

cover-date August 2019

details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_NLMPMC version:5.6.6.2 mode:remove_FC converted:24.07.2019

ScienceOpen disciplines: Molecular medicine

Keywords: antitumour effects,damage‐associated molecular patterns,dendritic cells,icd inducers,immune system,immunogenic cancer cell death

Data availability:

ScienceOpen disciplines: Molecular medicine

Keywords: antitumour effects, damage‐associated molecular patterns, dendritic cells, icd inducers, immune system, immunogenic cancer cell death

Immunogenic cell death in cancer therapy: Present and emerging inducers

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