Blog
About

7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis.

      The EMBO Journal

      Activins, antagonists & inhibitors, biosynthesis, genetics, Animals, Bone Morphogenetic Proteins, Cell Differentiation, Cell Division, Cloning, Molecular, Ear, abnormalities, Epidermis, Follistatin, Gene Expression Regulation, Growth Substances, Keratinocytes, cytology, Mice, Mice, Transgenic, Skin, injuries, Skin Abnormalities, Skin Physiological Phenomena, Transgenes, Wound Healing, physiology

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Recently, we demonstrated a strong upregulation of activin expression after skin injury. Furthermore, overexpression of this transforming growth factor beta family member in the skin of transgenic mice caused dermal fibrosis, epidermal hyperthickening and enhanced wound repair. However, the role of endogenous activin in wound healing has not been determined. To address this question we overexpressed the soluble activin antagonist follistatin in the epidermis of transgenic mice. These animals were born with open eyes, and the adult mice had larger ears, longer tails and reduced body weight compared with non-transgenic littermates. Their skin was characterized by a mild dermal and epidermal atrophy. After injury, a severe delay in wound healing was observed. In particular, granulation tissue formation was significantly reduced, leading to a major reduction in wound breaking strength. The wounds, however, finally healed, and the resulting scar area was smaller than in control animals. These results implicate an important function of endogenous activin in the control of wound repair and scar formation.

          Related collections

          Author and article information

          Journal
          11574468
          125651
          10.1093/emboj/20.19.5361

          Comments

          Comment on this article