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The economics of ribosome biosynthesis in yeast
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Abstract
In a rapidly growing yeast cell, 60% of total transcription is devoted to ribosomal
RNA, and 50% of RNA polymerase II transcription and 90% of mRNA splicing are devoted
to ribosomal proteins (RPs). Coordinate regulation of the approximately 150 rRNA genes
and 137 RP genes that make such prodigious use of resources is essential for the economy
of the cell. This is entrusted to a number of signal transduction pathways that can
abruptly induce or silence the ribosomal genes, leading to major implications for
the expression of other genes as well.