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      Efficacy and tolerability of a combination of Lyprinol and high concentrations of EPA and DHA in inflammatory rheumatoid disorders.

      Advances in Therapy

      Adult, Aged, Arthritis, Rheumatoid, diagnosis, drug therapy, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Therapy, Combination, Eicosapentaenoic Acid, administration & dosage, Female, Follow-Up Studies, Humans, Lipids, Male, Maximum Tolerated Dose, Middle Aged, Pain Measurement, Prospective Studies, Pyrones, Range of Motion, Articular, drug effects, physiology, Risk Assessment, Severity of Illness Index, Treatment Outcome

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          This 12-week drug-monitoring study was conducted to evaluate the efficacy of Sanhelios Mussel Lyprinol Lipid Complex on 50 adult men and women with inflammatory rheumatoid arthritis. A total of 34 patients required drug therapy before and during the study. By the end of the study, 21 (62%) patients were able to reduce their dosage and 13 were able to terminate drug therapy. At the end of the treatment period, 38% were regarded symptom free, and the number of patients with severe pain decreased significantly from 60% at baseline to 25% at the completion of the trial. A significant effect was observed for each investigated parameter. The special combination of Lyprinol and omega-3 fatty acids was generally very well tolerated, with only one, nonserious adverse event (mild nausea) reported. This dietary supplement may therefore be considered an effective and well-tolerated component of treatment regimens for inflammatory rheumatoid arthritis.

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