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      When ubiquitin meets NF-κB: a trove for anti-cancer drug development.

      1 ,
      Current pharmaceutical design

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          Abstract

          During the last two decades, the studies on ubiquitination in regulating transcription factor NF-κB activation have elucidated the expanding role of ubiquitination in modulating cellular events by non-proteolytic mechanisms, as well as by proteasomal degradation. The significance of ubiquitination has also been recognized in regulating gene transcription, epigenetic modifications, kinase activation, DNA repair and subcellular translocation. This progress has been translated into novel strategies for developing anti-cancer therapeutics, exemplified by the success of the first FDA-approved proteasome inhibitor drug Bortezomib. Here we discuss the current understanding of the ubiquitin-proteasome system and how it is involved in regulating NF-κB signaling pathways in response to a variety of stimuli. We also focus on the recent progress of anti-cancer drug development targeting various steps of ubiquitination process, and the potential of these drugs in cancer treatment as related to their impact on NF-κB activation.

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          Author and article information

          Journal
          Curr. Pharm. Des.
          Current pharmaceutical design
          1873-4286
          1381-6128
          2013
          : 19
          : 18
          Affiliations
          [1 ] Department of Pathology and Laboratory Medicine, Center for Adult Cancer Research, University of Tennessee Health Science Center, 19 S. Manassas St., Memphis, TN 38163, USA. zwu6@uthsc.edu
          Article
          CPD-EPUB-20121102-23 NIHMS505366
          10.2174/1381612811319180010
          3759360
          23151140
          50bb40cf-c5c9-4a25-863d-a6b5b5046567
          History

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