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      Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence

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          Abstract

          Adipocyte derived free fatty acids (FFA) promote epithelial ovarian cancer (EOC) by acting as a fuel source to support the energy requirement of the cancer cells. FFA may also exert biological effects through signaling pathways. Recently, a family of FFA activated G-protein coupled receptors (FFAR/GPCRs) was identified. Our objective was to investigate the role of FFAR/GPCRs in EOC and assess their potential as therapeutic targets.

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          Author and article information

          Journal
          Gynecologic Oncology
          Gynecologic Oncology
          Elsevier BV
          00908258
          April 2016
          April 2016
          : 141
          : 1
          : 72-79
          Article
          10.1016/j.ygyno.2016.02.026
          27016232
          50bbf505-10b9-4530-a457-50b1ae68900c
          © 2016

          https://www.elsevier.com/tdm/userlicense/1.0/

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