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      The cloning of a family of genes that encode the melanocortin receptors.

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          Abstract

          Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Aug 28 1992
          : 257
          : 5074
          Affiliations
          [1 ] Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201.
          Article
          10.1126/science.1325670
          1325670
          50c80b02-2cdb-4de2-9ed5-430c670cb22c
          History

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