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      The cloning of a family of genes that encode the melanocortin receptors.

      Science (New York, N.Y.)

      Adrenal Cortex, metabolism, Amino Acid Sequence, Animals, Blotting, Northern, Cloning, Molecular, Dose-Response Relationship, Drug, GTP-Binding Proteins, Humans, Melanocyte-Stimulating Hormones, physiology, Melanocytes, Mice, Molecular Sequence Data, Polymerase Chain Reaction, RNA, Messenger, biosynthesis, Receptors, Corticotropin, Receptors, Pituitary Hormone, genetics, Sequence Homology, Nucleic Acid

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          Abstract

          Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.

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          1325670

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