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Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer's Dementia in Individuals With Previous Depression.
Claudia Bartels
1 ,
Michael Wagner
1 ,
Steffen Wolfsgruber
1 ,
Hannelore Ehrenreich
1 ,
Anja Schneider
1
Mar 01 2018
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Abstract
Depression is associated with an increased risk of Alzheimer's disease. Research has shown that the selective serotonin reuptake inhibitor (SSRI) citalopram decreases amyloid-β generation and plaque load. The authors evaluated the impact of SSRI treatment on CSF biomarkers and progression from mild cognitive impairment (MCI) to Alzheimer's dementia.