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      Assessment of the Reproducibility of Nocturnal Growth Hormone Secretion

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          The reproducibility of measurements of nocturnal spontaneous secretion of growth hormone (GH) was assessed. The study population consisted of 15 short children with a variety of pathological conditions. Blood samples were taken every 20 min from each subject during sleep on two consecutive nights. The analysis of variance of matched series indicated a global reproducibility, but also demonstrated significant individual variabilities (within-subject effect) of both peak amplitude (p = 0.05) and mean concentration (p = 0.02). We did not find any link between the variation of the GH parameters and the variations of the clinical sleep score in 11 patients.

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          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 34
          : 1
          : 9-12
          aPediatric Endocrine Unit, bCentral Department of Nuclear Medicine, and cInformatics Department, University Hospital, Lille, France
          181787 Horm Res 1990;34:9–12
          © 1990 S. Karger AG, Basel

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          Pages: 4
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