CARD9 Syk-dependent and Raf-1 Syk-independent signaling pathways in target recognition of Candida albicans by Dectin-1.

Abstract

As a principle receptor to β-glucan in the Candida albicans cell wall, Dectin-1 performs recognition specifically and its mechanisms are diverse in different situations. With a view to developing certain antifungal targeted drugs, this review provides new insights into the novel immune signaling pathways induced by Dectin-1, especially the novel understandings of CARD9 in the Syk-dependent NF-κB pathway, and of Raf-1 in the Syk-independent NF-κB signaling pathway.