11
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Effect of Treatment with Salsalate, Menhaden Oil, Combination of Salsalate and Menhaden Oil, or Resolvin D1 of C57Bl/6J Type 1 Diabetic Mouse on Neuropathic Endpoints

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Aims. In this study a streptozotocin induced type 1 diabetes mouse model was used to assess the effectiveness of salsalate, menhaden oil, the combination of salsalate and menhaden oil, or resolvin D1 on neuropathic endpoints. Materials and Methods. Changes in body weight, blood glucose, serum markers for triglycerides, free fatty acids, cholesterol, and resolvin D1, motor and sensory nerve conduction velocities and thermal sensitivity were assessed, as well as performing in vivo confocal microscopy of subepithelial corneal nerves and immunohistochemistry of nerves in the cornea and foot pad. Results. Diabetic animals failed to gain weight and had elevated blood glucose levels. Diabetic mice had slowed nerve conduction velocity, reduced innervation of the foot pad and cornea subepithelial and epithelial layers, and reduced thermal sensitivity. Monotherapy treatment with salsalate, menhaden oil, and resolvin D1 reduced the pathological signs of diabetic neuropathy. The combination of salsalate and menhaden oil also reduced signs of pathology and generated elevated plasma levels of resolvin D1 compared to other groups. Conclusions. Additional studies are needed to determine whether the combination of salsalate and menhaden oil may be more efficacious than monotherapy alone for the treatment of diabetic peripheral neuropathy.

          Related collections

          Most cited references 32

          • Record: found
          • Abstract: not found
          • Article: not found

          Resolvins and protectins in inflammation resolution.

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            n-3 fatty acids in cardiovascular disease.

             R. Caterina (2011)
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients.

              The accurate detection, characterization and quantification of human diabetic neuropathy are important to define at risk patients, anticipate deterioration, and assess new therapies. Corneal confocal microscopy is a reiterative, rapid, non-invasive in vivo clinical examination technique capable of imaging corneal nerve fibres. The aim of this study was to define the ability of this technique to quantify the extent of degeneration and regeneration of corneal nerve fibres in diabetic patients with increasing neuropathic severity. We scanned the cornea and collected images of Bowman's layer (containing a rich nerve plexus) from 18 diabetic patients and 18 age-matched control subjects. Corneal nerve fibre density (F(3)=9.6, p<0.0001), length (F(3)=23.8, p<0.0001), and branch density (F(3)=13.9, p<0.0001) were reduced in diabetic patients compared with control subjects, with a tendency for greater reduction in these measures with increasing severity of neuropathy. Corneal confocal microscopy is a rapid, non-invasive in vivo clinical examination technique which accurately defines the extent of corneal nerve damage and repair and acts as a surrogate measure of somatic neuropathy in diabetic patients. It could represent an advance to define the severity of neuropathy and expedite assessment of therapeutic efficacy in clinical trials of human diabetic neuropathy.
                Bookmark

                Author and article information

                Journal
                J Nutr Metab
                J Nutr Metab
                JNME
                Journal of Nutrition and Metabolism
                Hindawi Publishing Corporation
                2090-0724
                2090-0732
                2016
                28 September 2016
                : 2016
                Affiliations
                1Department of Veterans Affairs Iowa City VA Health Care System, Iowa City, IA 52246, USA
                2Veterans Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, IA 52246, USA
                3Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
                4Department of Ophthalmology and Visual Science, University of Iowa, Iowa City, IA 52242, USA
                5Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA 52242, USA
                Author notes

                Academic Editor: Stan Kubow

                Article
                10.1155/2016/5905891
                5059581
                Copyright © 2016 Matthew S. Yorek et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Funding
                Funded by: Office of Research and Development
                Award ID: RX000889-01
                Funded by: Iowa City Veterans Affairs Center for the Prevention and Treatment of Visual Loss
                Award ID: C9251-C
                Funded by: National Institute of Diabetes and Digestive and Kidney Diseases
                Award ID: DK107339
                Categories
                Research Article

                Nutrition & Dietetics

                Comments

                Comment on this article