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      Validation of ethnopharmacological uses of Heliotropium strigosum Willd. as spasmolytic, bronchodilator and vasorelaxant remedy

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          Abstract

          Background

          Heliotropium strigosum is used in traditional medicine to manage gastrointestinal pain, respiratory distress and vascular disorders. The present study was undertaken to provide scientific evidences for these folkloric uses by in vitro experimental settings.

          Methods

          A crude methanol extract of the Heliotropium strigosum (Hs.Cr) was tested in vitro on isolated rabbit jejunum preparations to detect the possible presence of spasmolytic activity. Moreover, isolated rabbit tracheal and aorta preparations were used to ascertain the relaxant effects of the extract.

          Results

          The Hs.Cr exhibited relaxant effects in rabbit jejunum in a concentration dependent manner (0.01-3.0 mg/ml). The Hs.Cr also relaxed K + (80 mM)-induced spastic contractions in rabbit jejunum and shifted the Ca 2+ concentration response curves towards right. The extract relaxed carbachol (1 μM)- as well as K + (80 mM)-induced contractions in rabbit trachea at concentrations ranging from 0.01 to 10 mg/ml. Moreover, Hs.Cr. also relaxed (0.01-3.0 mg/ml) the phenylephrine (1 μM)- and K + (80 mM)-induced contractions in isolated rabbit aorta.

          Conclusions

          The Hs.Cr was found to exhibit spasmolytic, bronchodilator and vasorelaxant activities on isolated rabbit jejunum, trachea and aorta preparations, likely mediated through Ca 2+ channel blockade. This finding may provide a scientific basis for the folkloric uses of the plant.

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          Most cited references28

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          Calcium movements, distribution, and functions in smooth muscle.

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            Mechanisms of action of transmitters and other substances on smooth muscle.

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                Author and article information

                Contributors
                khjanbaz@hotmail.com
                sana.javedbzu@yahoo.com
                fatima2saqib@yahoo.com
                imran.ch@bzu.edu.pk
                ahirzia@gmail.com
                +39-089-959-751 , defeo@unisa.it
                Journal
                BMC Complement Altern Med
                BMC Complement Altern Med
                BMC Complementary and Alternative Medicine
                BioMed Central (London )
                1472-6882
                6 June 2015
                6 June 2015
                2015
                : 15
                : 169
                Affiliations
                [ ]Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
                [ ]Department of Pharmacognosy, University of Karachi, Karachi, Pakistan
                [ ]Department of Pharmacy, University of Salerno, Fisciano, Salerno Italy
                Article
                697
                10.1186/s12906-015-0697-1
                4458017
                5109f763-a872-44c7-815c-8451ec4e11f9
                © Janbaz et al. 2015

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 13 May 2015
                : 28 May 2015
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2015

                Complementary & Alternative medicine
                heliotropium strigosum,spasmolytic activity,bronchodilator activity,vasorelaxant activity

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